The risk factors related to liver injury in non-Intensive Care Unit (non-ICU) admitted patients infected with COVID-19

Authors

Abstract:

Background: Liver is one of the target organs for COVID-19 infection. The liver damage in critically ill patients was investigated in previous studies, but there is no available data about liver injury in mild to moderate form of infection with COVID019. In this study, we estimated the prognostic factors related to liver injury in NON-ICU admitted patients infected with COVID-19. Methods: in this retrospective study, 102 eligible adult participants admitted in the ward were included. Demographic characteristics, admission duration, underlying disease, manifestations of infection, and laboratory data were analyzed. Then, with statistical, univariate, and multivariate analysis, the associated and independent factors were estimated. Results: the mean age of the study population was 55.13± 17.02 years old. The most common symptom was fever (45.8%). The most frequent co-morbidity was hypertension (25%). 65 patients had liver injury (63.72%). According to statistical analysis CRP were significantly higher in liver injury group (P=0.01, respectively). Univariate analysis reported ALKP, and CRP associated significantly with liver injury (P=0.04, OR= 1.003, Cl 95%= 1.000-1.007; P=0.03, OR= 1.009, Cl 95%= 1.000- 1.017, respectively). No independent factor was detected in multivariate analysis. Based on Spearman’s rank correlation coefficients CRP and lymphocyte correlated significantly with AST (r=0.22, P=0.00; r=-0.13, P=0.09, respectively). Moreover, neutrophil, CRP, and lymphocyte correlated with ALT (r=0.27, P=0.01; r=0.23, P=0.02; r= -0.19, P=0.05, respectively). Conclusion: Although in the current study, no independent factor was detected, CRP had a significant association with liver injury. It appears the role of inflammatory pathways in the severity of this infection.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Clinical parameters and mortality in COVID-19 patients admitted to an intensive care unit (ICU) in Qazvin, Iran

Background: The initial reports of an outbreak of SARS-CoV-2 pneumonia suggest that COVID-19 is associated with severe disease. Objective: We aimed to describe the clinical parameters and mortality of patients with SARS-CoV-2 pneumonia admitted to intensive care Unit (ICU) of Velayat Hospital in Qazvin, Iran. Materials and methods: In this single-centered, cross-sectional and retrospective st...

full text

Risk Factors and Prognostic Factors of Acute Renal Failure in Patients Admitted to an Intensive Care Unit, Tehran-Iran

Acute renal failure (ARF) is defined as a sudden and continuous decrease of glomerular function associated with azotemia, and may be followed by decreased urinary output. There is a high incidence of ARF in ICU patients with a high mortality rate. Many factors can promote ARF development or influence its outcome. This study was done to assess the incidence, risk factors, outcome and treatme...

full text

Incidence and risk factors of upper gastrointestinal bleeding in pediatric intensive care unit admitted patients

Background and Objective: To assess the incidence and risk factors of upper gastrointestinal bleeding in children admitted to pediatric intensive care unit for more than 6 hrs. Methods: We prospectively collected medical records of children between 1 month and 18 years old admit-ted to our 10 bed PICU of a tertiary care university hospital between December 1, 2014 and May 30, 2015. De-mographi...

full text

family experiences of patients admitted in intensive care unit (icu)

background: the intensive care unit (icu) is one of the most stressful places for families thus; admission of a patient in this unit will influence other members of family and their functions. according to continuous presence of researcher in this ward, observing the stresses and concerning of the patients’ families and considering the valuable role of the experiences of the family in planning ...

full text

Predictive factors of deep vein thrombosis in patients admitted to intensive care unit

Background: Because deep vein thrombosis (DVT) is one of the most common problems in the intensive care unit, it may lead to complecating the patient's general condition. This study aimed to investigate the predictive factors of DVT in patients admitted to the intensive care unit (ICU) of Amin hospital in Isfahan. Methods: In this retrospective study, all the records of patients admitted to th...

full text

Incidence, risk factors and prognosis of nosocomial pneumonia in adult patients admitted in the intensive care unit

Introduction: Hospital acquired pneumonia (HAP) is the second most commonly reported hospital infection and the most common infection in the intensive care unit (ICU). Identification of risk factors and determinants of prognosis in the occurrence of HAP and ways of prevention can be effective in reducing the incidence and mortality of these infections. In this way, we investigated, the incidenc...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 11  issue Supplement 1

pages  8- 0

publication date 2020-10

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023